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creb inhibitor  (MedChemExpress)
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a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence <t>of</t> <t>PKA</t> inhibitor or <t>CREB</t> inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.
Creb Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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protein creb inhibitor  (MedChemExpress)
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MedChemExpress protein creb inhibitor
a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence <t>of</t> <t>PKA</t> inhibitor or <t>CREB</t> inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.
Protein Creb Inhibitor, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/creb+inhibitor/666-15/10__1097_slash_cm9__0000000000004077-47-37-43
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creb inhibitor  (Proteintech)
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Proteintech creb inhibitor
a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence <t>of</t> <t>PKA</t> inhibitor or <t>CREB</t> inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.
Creb Inhibitor, supplied by Proteintech, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/creb+inhibitor/CREB1+Fusion+Protein/us12564179-436-14-24
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creb inhibitor 666 159  (MedChemExpress)
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MedChemExpress creb inhibitor 666 159
a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence <t>of</t> <t>PKA</t> inhibitor or <t>CREB</t> inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.
Creb Inhibitor 666 159, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/creb+inhibitor/CREB1+Antibody/pmc13044252-103-111-123
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camp response element binding creb inhibitor kg 501  (MedChemExpress)
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MedChemExpress camp response element binding creb inhibitor kg 501
a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence <t>of</t> <t>PKA</t> inhibitor or <t>CREB</t> inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.
Camp Response Element Binding Creb Inhibitor Kg 501, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/creb+inhibitor/KG-501/pm41592399-67-19-28
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creb inhibitor 666 15  (MedChemExpress)
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MedChemExpress creb inhibitor 666 15
a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence <t>of</t> <t>PKA</t> inhibitor or <t>CREB</t> inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.
Creb Inhibitor 666 15, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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calcium creb signaling  (MedChemExpress)
94
MedChemExpress calcium creb signaling
a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence <t>of</t> <t>PKA</t> inhibitor or <t>CREB</t> inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.
Calcium Creb Signaling, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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creb inhibitor kg501  (MedChemExpress)
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MedChemExpress creb inhibitor kg501
a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence <t>of</t> <t>PKA</t> inhibitor or <t>CREB</t> inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.
Creb Inhibitor Kg501, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.

Journal: Nature Communications

Article Title: Catecholaminergic neurons boost fibroblast osteogenic activity in keloid

doi: 10.1038/s41467-026-72823-9

Figure Lengend Snippet: a cAMP quantitation of keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 2 biologically independent samples for fibroblasts treated with epinephrine in the presence of metoprolol, and n = 3 biologically independent samples for other groups). b qPCR analysis of TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 6 h ( n = 4 biologically independent samples for fibroblasts treated with epinephrine in the presence of CREB inhibitor, and n = 5 biologically independent samples for other groups). c Immunoblotting and quantitative analysis of IBSP and TSN expression in keloid fibroblasts treated or not with epinephrine in the presence or absence of PKA inhibitor or CREB inhibitor for 24 h ( n = 3 biologically independent samples). d qPCR analysis of the abundance of the TSN promoter that immunoprecipitated with αCREB1 or IgG control in keloid fibroblasts treated or not with epinephrine in the presence or absence of metoprolol for 30 min ( n = 6 biologically independent samples for Epinephrine-CREB1 and Epinephrine & Metoprolol-CREB1, and n = 5 biologically independent samples for other groups). Data are presented as the percentages of αCREB1- or IgG-pulled TSN promoter relative to that in the input. Data represent the mean ± SD; p -values were determined by one-way ANOVA. Data are representative of at least 2 independent experiments.

Article Snippet: For the assays involving PKA or CREB antagonism, keloid fibroblasts were treated with 1 μM PKA Inhibitor Fragment (6-22) amide TFA (MCE cat. HY-P1290A) or the CREB inhibitor 666-15 (MCE cat. HY-101120) for 1 h before the addition of epinephrine.

Techniques: Quantitation Assay, Expressing, Western Blot, Immunoprecipitation, Control